Neurotrophic factors: promising candidates in tissue regeneration
نویسندگان
چکیده
منابع مشابه
Peripheral nerve regeneration and neurotrophic factors.
The role of neurotrophic factors in the maintenance and survival of peripheral neuronal cells has been the subject of numerous studies. Administration of exogenous neurotrophic factors after nerve injury has been shown to mimic the effect of target organ-derived trophic factors on neuronal cells. After axotomy and during peripheral nerve regeneration, the neurotrophins NGF, NT-3 and BDNF show a...
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The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that elicits protective reflexes such as blinking and tearing and exerts trophic supp...
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Stem cells are the “master “ cells of our body that act as building block to regenerate and turn into cells that form tissues, organs and systems in the human body. Several “loci ’’ or “niches” within the adult human body are colonised by a significant number of stem cells. However, access to these potential collection sites often is a limiting point. Growing evidence demonstrates that stem cel...
متن کاملPeripheral Nerve Regeneration: Cell Therapy and Neurotrophic Factors.
Peripheral nerve trauma results in functional loss in the innervated organ, and recovery without surgical intervention is rare. Many surgical techniques can be used for nerve repair. Among these, the tubulization technique can be highlighted: this allows regenerative factors to be introduced into the chamber. Cell therapy and tissue engineering have arisen as an alternative for stimulating and ...
متن کاملCorneal Epithelium-Derived Neurotrophic Factors Promote Nerve Regeneration.
Purpose To explore the neurotrophic factor expression in corneal epithelium and evaluate their effects on the trigeminal ganglion (TG) neurite outgrowth and corneal nerve regeneration in mice. Methods The expression of neurotrophic factors was compared among the intact, regenerating, and regenerated mouse corneal epithelium. Mouse primary TG neurons were treated with the conditioned medium of...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2016
ISSN: 1673-5374
DOI: 10.4103/1673-5374.182696